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DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells (Dr. Niimi and Prof. Nakano)

DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells (Dr. Niimi and Prof. Nakano)

 

Dr. Atsuko Niimi and Prof. Takashi Nakano (GIAR, Heavy Ion Therapy Research Program), by collaborating with Shibata Lab (Dr. Atsushi Shibata, Education and Research Support Center, Gunma University), investigated the mechanism of PD-L1 upregulation in response to DNA damage. Our findings demonstrated the involvement of DSB repair in PD-L1 expression and provided mechanistic insight into how PD-L1 expression is regulated after DNA damage.

 

Online URL:

http://www.nature.com/articles/s41467-017-01883-9

 

 

 

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