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ラボラトリー
国立大学法人 群馬大学
JREC-IN

統合腫瘍学

重粒子線治療研究プログラム

English
中野 隆史中野 隆史 プログラムディレクター
職名:教授
○研究室:腫瘍放射線学教室
○関連サイト: ・腫瘍放射線学教室
 http://radiology.dept.med.gunma-u.ac.jp/
・重粒子線医学研究センター
 http://heavy-ion.showa.gunma-u.ac.jp/index.php

国立大学唯一の重粒子線照射施設を活かした、重イオンマイクロサージェリーによるがん治療の高度化並びに治療対象の拡大のための重粒子線照射技術の研究開発、及び分子標的薬剤等との併用による難治性がんの克服を目指す臨床開発研究を行います。

田代 睦
職名:准教授

研究テーマ

「重粒子線治療の照射精度向上のためのシステム開発および物理工学的研究」 

・呼吸性移動臓器の照射精度向上に関する研究

移動に伴う標的のずれや、標的までのビーム経路の構造が変化することによる、標的への線量不足や周辺正常組織への過剰線量を検証し、最適な治療計画や照射条件を得ることを目指している。

・患者位置決め時の体内移動の定量化および可視化に関する研究

照射直前に取得する直交2方向の2次元X線画像と治療計画時の3次元CT画像から得られる擬似X線画像との2D-3Dオートマッチングによる患者位置決め技術を応用し、患者体内の移動や変形に対して、各所の移動量を定量化・可視化する技術開発研究を行っている。

・患者状態の変化に即時対応する照射システムの開発

日々の患者状態の変化に対して、その線量分布への影響、治療計画の変更最適化、変更に対応した治療照射をオンデマンドで可能とする照射システムの開発を目指している。

主要業績

 

論文

Tashiro M, Ishii T, Koya J, Okada R, Kurosawa Y, Arai K, Abe S, Ohashi Y, Shimada H, Yusa K, Kanai T, Yamada S, Kawamura H, Ebara T, Ohno T, Nakano T. Technical approach to individualized respiratory-gated carbon-ion therapy for mobile organs. Radiological Physics and Technology, 6: 356-366, 2013.

Tashiro M, Minohara S, Kanai T, Yusa K, Sakurai H, Nakano T. Three-dimensional velocity mapping of lung motion using vessel bifurcation pattern matching. Medical Physics, 33: 1747-1757, 2006.

・田代 睦. 群馬大学重粒子線医学センターのご紹介. 放射線化学, 92: 33-37, 2011.

・Tajiri S, Tashiro M, Mizukami T, Tsukishima C, Torikoshi M, Kanai T. Margin estimation and disturbances of irradiation field in layer-stacking carbon-ion beams for respiratory moving targets. Journal of Radiation Research, 2017 Feb 23:1-9.

・Ebara T, Shimada H, Kawamura H, Shirai K, Saito J, Kawashima M, Tashiro M, Ohno T, Kanai T, Nakano T. Dosimetric Analysis Between Carbon Ion Radiotherapy and Stereotactic Body Radiotherapy in Stage I Lung Cancer. Anticancer Research, 34(9): 5099-5104, 2014.

・Sakama M, Kanai T, Kase Y, Yusa K, Tashiro M, Torikai K, Shimada H, Yamada S, Ohno T, Nakano T. Design of ridge filters for spread-out Bragg peaks with Monte Carlo simulation in carbon ion therapy. Physics in Medicine and Biology, 57: 6615-6633, 2012.

 

学会発表

Tashiro M, Ishii T, Koya J, Okada R, Kurosawa Y, Arai K, Abe S, Ohashi Y, Shimada H, Yusa K, Kanai T, Yamada S, Kawamura H, Ebara T, Ohno T, Nakano T. Technical approach to individualized respiratory-gated carbon-ion therapy for mobile organs. JRC2014, Yokohama, 2014.

Tashiro M. Respiratory motion management for carbon-ion therapy at GHMC. The 2nd International Symposium of Gunma University Program for Leading Graduate Schools, Maebashi, 2014.

 

受賞

・Radiological Physics and Technology, Doi Award in Radiation Therapy Physics, Japanese Society of Radiological Technology, Japan Society of Medical Physics, April 13, 2014.

・Poster Award (Radiation Therapy), The 4th Japan-Korea Joint Meeting on Medical Physics and The 5th Asia-Oceania Congress of Medical Physics, Sep. 30, 2005.


Raj Kumar PARAJULI
職名:研究員

研究テーマ

Development of Compton Imaging System

Characterization of cancer with respect to its surroundings tissue is a very important aspect of current medical imaging systems, which can ease the medical diagnosis and treatment strategy. Even with the current imaging techniques like PET and SPECT, the problems remain unsolved because of the imaging principles; requirement of a mechanical collimator or coincident detection of annihilation gamma rays. Effective use of Compton cameras, which were originally developed for astronomy, could be a great innovation to overcome the current problems in diagnostic imaging because of its simultaneous imaging ability against wide energy range. Currently we are developing a 3-dimentional nuclear imaging system based on the high-tech Si/CdTe semiconductor cameras developed by Japan Aerospace Exploration Agency (JAXA). In the meanwhile we are also implementing our immense effort in enhancing the resolution and accuracy of current imaging technique followed by developing high speed imaging mechanism.

Radiation Measurement using RPL glass Micro-dosimeter

Heavy Ion Cancer therapy has been increasing worldwide due to its high linear transfer (LET) and unique dose distribution at Bragg peak with sharp increase of dose in well-defined depth and rapid fall-off beyond that maximum. In this research, we attempt to enhance the current system by developing a precise dose distribution measurement tool so called the micro-dosimeter, which is necessary to treat cancer with high accuracy minimizing the side effects. If we can develop and implement highly reliable radio-photoluminescence (RPL) glass dosimeter with size less than millimeters, it could be possible to visualize three-dimensional dose distribution. Therefore in this research we aim to develop micrometer sized radiation dosimeter for realizing convenient three-dimensional dose distribution evaluation method for radiation therapy.

主要業績

論文

・W. Kada, S. Kawabata, T. Satoh, M. Sakai, R. K. Parajuli, N. Yamada, M. Koka, K. Miura, O. Hanaizumi, and T. Kamiya, “Observation of Changes in Ion Beam Induced Luminescence Spectra from Organics during Focused Microbeam Irradiation”, Nucl. Instr. Meth. B, 2017(Peer Review,In Press)

・W. Kada, S. Kawabata, T. Satoh, R. K. Parajuli, N. Yamada, M. Koka, K. Miura, O. Hanaizumi, and T. Kamiya, “Development of High-speed Wavelength-dispersive IBIL Analysis and Imaging System Using a Multi-channel Photon-counting Spectrometer”, Nucl. Instr. Meth. B, 2017 (Peer Review,InPress)

・S. Kawabata, W. Kada, Y. Matsubara, T. Satoh, M. Sakai, R. K. Parajuli, N. Yamada, M. Koka, K. Miura, O. Hanaizumi, and T. Kamiya, “Micro-PIXE Analysis and Imaging of Radio-photoluminescence Glass Bead Microdosimeters”, Nucl. Instr. Meth. B, 2017 (Peer Review,InPress)

・R. K. Parajuli, R. Saruya, N. Akutzu, S. Miura, W. Kada, S. Kawabata, Y. Matsubara, T. Satoh, M. Koka, N. Yamada, T. Kamiya, K. Miura, and O. Hanaizumi, “Fabrication and Evaluation of Flexible Mach-Zehnder Waveguide Structure Embedded in a Poly(dimethylsiloxane) Thin Film using a Proton Microbeam”, Jpn. J. Appl. Phys., 55 (2016) 06GD01. (Peer Review)

・R. K. Parajuli, W. Kada, S. Kawabata, Y. Matsubara, K. Miura, A. Yokoyama, M. Haruyama, M. Sakai, and O. Hanaizumi, “ Evaluation of Radio-photoluminescence Spectra of Copper-doped Phosphate Glass Dosimeter Irradiated with Ionized Particles”, Key. Eng. Mat., 698 (2016) 163-170. (Peer Review)

・R. K. Parajuli, W. Kada, S. Kawabata, Y. Matsubara, M. Sakai, K. Miura, T. Satoh, M. Koka, N. Yamada, T. Kamiya, and O. Hanaizumi, “Ion Beam Induced Luminescence (IBIL) Analysis for β-SiAlON:Eu Scintillator under Focused Micro-beam Irradiation”, Sen. Mat., 28 (2016) 837-844 (Peer Review)

・S. Kawabata, W. kada, R. K. Parajuli, Y. Matsubara, K. Miura, T. Satoh, M. Koka, N. Yamada, T. Kamiya and O. Hanaizumi, “ Complex system of Proton Beam Writing (PBW) and In-situ Ion Beam Induced Luminescence (IBIL) Analysis using Proton Microbeam Probe for the Evaluation of Micrometer-sized RPL Glass Dosimeter”, Jpn. J. Appl. Phys., 55 (2016) 06GD03. (Peer Review)

・R. K. Parajuli, N. Sunaguchi, R. Tei, T. Iijima, and Y. Yamakoshi, “Characterization of nonlinearity of shear elasticity using local velocity mapping”, Jpn. J. Appl. Phys. 53 (2014) 07KF30. (Peer Review)

・R. K. Parajuli, R. Tei, D. Nakai, and Y. Yamakoshi, “Share wave imaging using phase modulation component of harmonic distortion in continuous shear wave excitation”, Jpn. J. Appl. Phys. 52 (2013) 07HF22. (Peer Review)

・T. Miwa, Y. Yoshihara, K. Kanzawa, R. K. Parajuli, and Y. Yamakoshi, “Tissue viscoelasticity measurement system by simultaneous multiple-frequency excitation”, Jpn. J. Appl. Phys. 51 (2012) 07GF13. (Peer Review)

・T. Miwa, R. K. Parajuli, R. Tomizawa, and Y. Yamakoshi, “Shear wave velocity estimation by virtual sensing array spectrum analysis”, Jpn. J. Appl. Phys. 50 (2011) 07HF07. (Peer Review)

 

Presentations

1 . M. Sakai, R. K. Parajuli, M. Kikichi, K. Arakawa, M. Yamaguchi, Y. Nagao, N. Kawachi, S. Takeda, T. Takahashi, T. Nakano, “Comparison of Yttrium-90 Compton Image, SPECT, and PET”, 113th Japan Society of Medical Physics, Yokohama, Japan, 2017.

2 . R. K. Parajuli, W. Kada, M. Sakai, S. Kawabata, Y. Matsubara, T. Kamiya, T. Satoh, K. Miura, and O. Hanaizumi, “Evaluation of Radio-photoluminescence Glass Beads Dosimeter using Micro-PIXE Analysis and Imaging”, 77th Japan Society of applied Physics Autumn Meeting, Niigata, Japan, 2016.

3 . M. Sakai, M. Kikuchi, R. K. Parajuli, Y. Kubota, K. Arakawa, M. Yamaguchi, Y. Nagao, N. Kawachi, S. Fujimaki, T. Kamiya, K. Torikai, S. Takeda, S. Watanabe, T. Takahashi, T. Nakano, and M. Torikoshi,“ 3-Dimentional Nuclear Medical Imaging with Compton Camera”, 112th Japan Society of Medical Physics, Okinawa, Japan, 2016.

4 . M. Sakai, R. K. Parajuli, T. Ishii, S. Kawabata, and W. Kada, “Y-90 Bremsstrahlung Imaging with Compton Camera”, 3rd International Symposium of Gunma University Medical Innovation and 8th International Conference on Advanced Micro-Device Engineering, Kiryu, Japan, 2016. (Conference/Symposium).

5 . S. Kawabata, W. Kada, Y. Matsubara, T. Satoh, M. Koka, M. Sakai, R. K. Parajuli, N.Yamada, K. Miura, O. Hanaizumi, and T. Kamiya,“ Micro-PIXE analysis and Imaging of Radio-photoluminescence Glass Beads Dosimeter Designed for Micro-dosimetry”, 12th European Conference on Accelerators in Applied Physics and Technology (ECAART12), Finland, 2016. (Conference)

6 . Y. Matsubara, W. Kada, S. Kawabata, M. Sakai, R. K. Parajuli, K. Miura, T. Satoh, M.Koka, N. Yamada, T. Kamiya and O. Hanaizumi,“ Development and Simple Evaluation of Radio-photoluminescence Glass Dosimeter with Copper Activator for Convenient Three Dimensional Radiation Dosimetry”, 3rd International Symposium of Gunma University Medical Innovation and 8th International Conference on Advanced Micro-Device Engineering, Kiryu, Japan, 2016. (Conference/Symposium)

7 . T. Sekine, R. K. Parajuli, S. Kawabata, Y. Matsubara, W. Kada, M. Sakai, K.Miura, T. Satoh, M. Koka, N. Yamada, T. Kamiya and O. Hanaizumi, “Evaluation of Radiation Tolerance of α – and β -SiAlON scintillators under Intense Proton Beam Irradiation Using Ion Beam Induced Luminescence (IBIL) Analysis”,3rd International Symposium of Gunma University Medical Innovation and 8th International Conference on Advanced Micro-Device Engineering, Kiryu, Japan, 2016. (Conference/Symposium)

8 . R. K. Parajuli, R. Saruya, K. Miura, W. Kada, S. Kawabata, Y. Matsubara, H. Kato, A.Yokoyama, M. Koka, T. Satoh, Y. Ishii, T. Kamiya, H. Nishikawa and O. Hanaizumi, “Fabrication and In-situ Evaluation of Completely-Flexible MZ Waveguide Structure Embedded in PDMS Thin Film using Focused Proton Microbeam”, 28th International Microprocesses and Nanotechnology Conference, Toyama, Japan, 2015. (Conference)

9 . R. K. Parajuli, S. Kawabata, Y. Matsubara, W. Kada, M. Sakai, K. Miura, T.Satoh, M.Koka, N. Yamada, T. Kamiya, and O. Hanaizumi,“ Radiation Tolerability Evaluation of SiAlON Scintillator using Ion Beam Induced Luminescence (IBIL) Analysis”, 76th Japan Society of applied Physics Autumn Meeting, Nagoya, Japan, 2015. (Autumn Meeting).

10. R. K. Parajuli, and Y. Yamakoshi,“ Impact of Odd-Even Phase Modulated Harmonic Components in Nonlinearity of Shear Elasticity”, The 35th Symposium on Ultrasonic Electronics, Tokyo, Japan, 2014. (Symposium)

11. R. K. Parajuli, and Y. Yamakoshi, “Analysis of Local Velocity Map using Odd and Even Harmonic Phase Modulated Components of Shear Wave Propagation” 1st International Symposium of Gunma University Medical Innovation and 6th International Conference on Advanced Micro-Device Engineering, Kiryu, Japan,2014. (Conference/Symposium)

受賞

・Research Grant from “Gunma University Human Resources Cultivation Center” (HRCC) (2012~2013 -2 years.)

・Financial Support by “Tsuji Asia Scholarship Foundation, Sanrio” (April 2011~March 2013- 2 years)

・Full Scholarship sponsored by “Nepal Anti-Tuberculosis Association”(August 2003~July 2008- 4 years)

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