採用情報
ラボラトリー
国立大学法人 群馬大学
JREC-IN

内分泌代謝・シグナル学

神経シグナル学研究プログラム

English
平井 宏和平井 宏和 プログラムディレクター
職名:教授
○研究室: 神経生理学
○関連サイト:
・神経生理学 http://synapse.dept.med.gunma-u.ac.jp/

神経細胞の恒常性維持機構および、その破綻に起因する神経変性シグナルの解明による難治性神経疾患の治療法開発研究を行います。

業績

1.Shinohara Y, Konno A, Takahashi N, Matsuzaki Y, Kishi S, Hirai H.
Viral Vector-Based Dissection of Marmoset GFAP Promoter in Mouse and Marmoset Brains. PLoS One. 2016 Aug 29;11(8):e0162023.

2.Shinohara Y, Ohtani T, Konno A, Hirai H.
Viral Vector-Based Evaluation of Regulatory Regions in the Neuron-Specific Enolase(NSE) Promoter in Mouse Cerebellum In Vivo. Cerebellum. 2017 May 15. [Epub ahead of print]

3.Nitta K, Matsuzaki Y, Konno A, Hirai H.
Minimal Purkinje cell-specific PCP2/L7 promoter virally available for rodents and nonhuman primates. Mol Ther Methods Clin Dev. 2017 Sep;6:159-170.

4.Huda F, Konno A. Matsuzaki Y. Goenawan H. Miyake K. Shimada T, Hirai H.
Distinct transduction profiles in the CNS via three injection routes of AAV9 and the application to generation of a neurodegenerative mouse model. Mol Ther Methods Clin Dev. 2014 Aug 6;1:14032. doi: 10.1038/mtm.2014.32. eCollection 2014.

5.Matsuzaki Y, Konno A, Mukai R, Honda F, Hirato M, Yoshimoto Y, Hirai H.
Transduction Profile of the Marmoset Central Nervous System Using Adeno-Associated Virus Serotype 9 Vectors. Mol Neurobiol. 2017 Apr;54(3):1745-1758. Epub 2016 Feb 16.

6.Shuvaev AN, Hosoi N, Sato Y, Yanagihara D, Hirai H.
Progressive impairment of cerebellar mGluR signalling and its therapeutic potential for cerebellar ataxia in spinocerebellar ataxia type 1 model mice. Journal of Physiology. 2017 Jan 1;595(1):141-164. Epub 2016 Sep 15.

7.Matsuura S, Shuvaev AN, Iizuka A, Nakamura K, Hirai H.
Mesenchymal Stem Cells Ameliorate Cerebellar Pathology in a Mouse Model of Spinocerebellar Ataxia Type 1. Cerebellum 2014 Jun;13(3):323-30.

8.Mieda T, Suto N, Iizuka A, Matsuura S, Iizuka H, Takagishi K, Nakamura K, Hirai H.
Mesenchymal stem cells attenuate peripheral neuronal degenerat ion in spinocerebellar ataxia type 1 knockin mice. J Neurosci Res. 2016 Mar;94(3):246-52.

9.Suto N, Mieda T, Iizuka A, Nakamura K, Hirai H.
Morphological and Functional Attenuation of Degeneration of Peripheral Neurons by Mesenchymal Stem Cell-Conditioned Medium in Spinocerebellar Ataxia Type 1-Knock-in Mice. CNS Neuroscience & Therapeutics. 2016 Aug;22(8):670-6.

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