採用情報
ラボラトリー
国立大学法人 群馬大学
JREC-IN

 統合腫瘍学

オミックス医学研究プログラム

English
西山 正彦西山 正彦 プログラムディレクター
職名:教授
○研究室:病態腫瘍薬理学講座
○関連サイト:
・病態腫瘍薬理学講座 http://ocd.med.gunma-u.ac.jp/

生活習慣病、がんの創薬及び個別化医療の確立を可能とする、網羅的分子情報(オミックス情報)を基盤とした医療開発研究を行います。

業績

1 .Kaira K, Yokobori T, Nishiyama M, et al. Metabolic activity by 18F-FDG-PET/CT is predictive of early response after nivolumab in previously treated NSCLC. Eur J Nucl Med Mol Imaging. 2017 Aug 21. doi: 10.1007/s00259-017-3806-1. [Epub ahead of print]

2 .Bai T, Yokobori T, Nishiyama M, et al. High STMN1 level is associated with chemo-resistance and poor prognosis in gastric cancer patients. Br J Cancer. 2017;116(9):1177.

3 .Arai H, Kawabata-Iwakawa R, Nishiyama M, et al. Myeloid sarcoma arising in malignant phyllodes tumour: clonal relationships revealed by comparative genomewide analyses. Br J Haematol. 2017 Feb 17. [Epub ahead of print]

4 .Tsukagoshi M, Yokobori T, Nishiyama M, et al. Overexpression of karyopherin- α 2 in cholangiocarcinoma correlates with poor prognosis and gemcitabine sensitibity vianuckear translocation of DNA repair proteins. Oncotarget. 2017 Feb 2. doi: 10.18632/oncotarget.・15020. [Epub ahead of print]

5 .George J, Iwakawa R, et al. Genomic Amplification of CD274 (PD-L1) in Small-Cell Lung Cancer. Clin Cancer Res. 2017;23(5):1220.

6 .Otaka Y, Kawabata R, Yoshiyama S, Yokobori T, Prives C, Nishiyama M, et al. STXBP4 drives tumor growth and is associated with poor prognosis through PDGF Receptor signaling in lung squamous cell carcinoma. Clin Cancer Res. 2017;23(13):3442.

7 .Blomme A, Yokobori T, Nishiyama M, Castronovo V, Turtoi A, et al. Myoferlin regulates cellular lipid metabolism and promotes metastases in triple-negative breast cancer. Oncogene. 2017;36(15):2116.

8 .Altan B, Yokobori T, Nishiyama M, et al. Nuclear PRMT1 expression is associated with poor prognosis and chemosensitivity in gastric cancer patients. Gastric Cancer. 2016;19(3):789.

9 .Ueo H, Yokobori T, et al. Circulating tumour cell-derived plastin3 is a novel marker for predicting long-term prognosis in patients with breast cancer. Br J Cancer. 2015;112(9):1519.

10.Simo-Riudalbas L, Iwakawa R, et al. KAT6B is a tumor suppressor histone H3 lysine 23 acetyltransferase undergoing genomic loss in small cell lung cancer. Cancer Res. 2015;75(18):3936.

11.George J, Iwakawa R, et al. Comprehensive genomic profiles of small cell lung cancer. Nature. 2015;524(7563):47.

・Intellectual Property

1.①Title: Method for developing peripheral nerve cells from human induced pluripotent stem cells and use thereof , ②Country (Application No. and Date): Japan (2016-207211,21.10.2016) ③ Inventor: Masahiko Nishiyama; Susumu Rokudai; Shinji Yoshiyama,

2.①Title: Method for determining sensitivity to irinotecan and use thereof, ②Country (Grant No., and Grant Date): Au (2010222334; 21.05.2015), EP (2010750607;02.12.2015), US (13203810; 18.08.2015), ③ Inventor: Masahiko Nishiyama; Keiko Hiyama; Keiji Tanimoto; Norio Masuko

3.① Title: Marker for determination of sensitivity to triplet combination anti-cancer agent, ② Country (Grant No., and Granted Date): Au (2011337612; 29.09.2016),EP (2011846035; 26.04.2017), US (13991318; 17.03.2015), ③Inventor: Masahiko Nishiyama; Hidetaka Eguchi; Satoru Wada

4.①Title: Gene involved in immortalization of human cancer cells and use thereof, ②Country (Grant No., and Granted Date): CA (22654978; 10.05.2016), ③ Inventor:Masahiko Nishiyama; Keiko Hiyama; Keiji Tanimoto; Norio Masuko


川端 麗香
助教

業績

<論文>

1 . Bao P, Yokobori T, Altan B, Iijima M, Azuma Y, Onozato R, Yajima T, Watanabe A, Mogi A, Shimizu K, Nagashima T, Ohtaki Y, Obayashi K, Nakazawa S, Bai T, Kawabata-Iwakawa R, Asao T, Kaira K, Nishiyama M, Kuwano H. High STMN1 Expression is Associated with Cancer Progression and Chemo-Resistance in Lung Squamous Cell Carcinoma. Ann Surg Oncol. 2017 Dec;24(13):4017-4024.

2 . Sundaresan V, Lin VT, Liang F, Kaye FJ, Kawabata-Iwakawa R, Shiraishi K, Kohno T,Yokota J, Zhou L. Significantly mutated genes and regulatory pathways in SCLC-a meta-analysis. Cancer Genetics, 216-217: 20-28, 2017.

3 . Handa T, Katayama A, Yokobori T, Yamane A, Horiguchi J, Kawabata-Iwakawa R,Rokudai S, Bao P, Gombodorj N, Altan B, Kaira K, Asao T, Kuwano H, Nishiyama M, Oyama T. Caspase14 expression is associated with triple negative phenotypes and cancer stem cell marker expression in breast cancer patients. J Surg Oncol. In press, 2017.

4 . Gombodorj N, Yokobori T, Yoshiyama S, Kawabata-Iwakawa R, Rokudai S, Horikoshi I, Nishiyama M, Nakano T. Inhibition of Ubiquitin-conjugating Enzyme E2 May Activate the Degradation of Hypoxia-inducible Factors and, thus, Overcome Cellular Resistance to Radiation in Colorectal Cancer. Anticancer Res. 37(5):2425-2436, 2017.

5 . Otaka Y, Rokudai S, Kaira K, Fujieda M, Horikoshi I, Iwakawa-Kawabata R, Yoshiyama S, Yokobori T, Ohtaki Y, Shimizu K, Oyama T, Tamura J, Prives C, Nishiyama M. STXBP4 drives tumor growth and is associated with poor prognosis through PDGF Receptor signaling in lung squamous cell carcinoma. Clinical Cancer Research. 23(13):3442-3452, 2017.

6 . Arai H, Nobusawa S, Kawabata-Iwakawa R, Rokudai S, Higuchi T, Yamazaki T, Horiguchi J, Sano T, Kojima M, Nishiyama M, Yokoo H, Hirato J, Oyama T. Myeloid sarcoma arising in malignant phyllodes tumour: clonal relationships revealed by comparative genome-wide analyses. Br J Haematol. in press, 2017.

7 . George J, Saito M, Tsuta K, Iwakawa R, Shiraishi K, Scheel A, Uchida S, Watanabe SI, Nishikawa R, Noguchi M, Peifer M, Petersen I, Jang SJ, Buttners R, Harris CC, Yokota J, Thomas RK, Kohno T. Genomic amplification of CD274 (PD-L1) in small cell lung cancer. Clin Cancer Res. 23(5):1220-1226, 2017.

8 . Tsuboi M, Yamane A, Horiguchi J, Yokobori T, Kawabata-Iwakawa R, Yoshiyama S, Rokudai S, Odawara H, Tokiniwa H, Oyama T, Takeyoshi I, Nishiyama M. APOBEC3B high expression status is associated with aggressive phenotype in Japanese breast cancers. Breast Cancer. 23(5):780-8, 2016.

9 . Takahashi H, Sakakura K, Kawabata-Iwakawa R, Rokudai S, Toyoda M, Nishiyama M,Chikamatsu K. Immunosuppressive activity of cancer-associated fibroblasts in head and neck squamous cell carcinoma. Cancer Immunol Immunother. 64(11):1407-17, 2015.

10 . Simo-Riudalbas L, Perez-Salvia M, Setien F, Villanueva A, Moutinho C, Martinez-Cardus A, Moran S, Berdasco M, Gomez A, Vidal E, Soler M, Heyn H, Vaquero A, de la Torre C, Barcelo-Batllori S, Vidal A, Roz L, Pastorino U, Szakszon K, Borck G, Moura C, Carneiro F, Zondervan I, Savola S, Iwakawa R, Kohno T, Yokota J, Esteller M. KAT6B is a tumor suppressor histone H3 lysine 23 acetyltransferase undergoing genomic loss in small cell lung cancer. Cancer Res. 75(18):3936-45, 2015.

11. George J, Lim JS, Jang SJ, Cun Y, Ozretić L, Kong G, Leenders F, Lu X, Fernàndez-Cuesta L, Bosco G, Müller C, Dahmen I, Jahchan NS, Park KS, Yang D, Karnezis AN, Vaka D, Torres A, Wang MS, Korbel JO, Menon R, Chun SM, Kim D, Wilkerson M, Hayes N, Engelmann D, Pützer B, Bos M, Michels S, Vlasic I, Seidel D, Pinther B, Schaub P, Becker C, Altmüller J, Yokota J, Kohno T, Iwakawa R, Tsuta K, Noguchi M, Muley T, Hoffmann H, Schnabel PA, Petersen I, Chen Y, Soltermann A, Tischler V, Choi CM, Kim YH, Massion PP, Zou Y, Jovanovic D, Kontic M, Wright GM, Russell PA, Solomon B, Koch I, Lindner M, Muscarella LA, la Torre A, Field JK, Jakopovic M, Knezevic J, Castaños-Vèlez E, Roz L, Pastorino U, Brustugun OT, Lund-Iversen M, Thunnissen E, Köhler J, Schuler M, Botling J, Sandelin M, Sanchez-Cespedes M, Salvesen HB, Achter V, Lang U, Bogus M, Schneider PM, Zander T, Ansèn S, Hallek M, Wolf J, Vingron M, Yatabe Y, Travis WD, Nürnberg P, Reinhardt C, Perner S, Heukamp L, Büttner R, Haas SA, Brambilla E, Peifer M, Sage J, Thomas RK. Comprehensive genomic profiles of small cell lung cancer. Nature. 524(7563):47-53,
2015.

12. Iwakawa R, Kohno T, Totoki Y, Shibata T, Tsuchihara K, Mimaki S, Tsuta K, Narita Y, Nishikawa R, Noguchi M, Harris C, Robles A, Yamaguchi R, Imoto S, Miyano S, Totsuka H, Yoshida T, Yokota J. Expression and Clinical Significance of Genes Frequently Mutated in Small Cell Lung Cancers Defined by Whole Exome/RNA Sequencing. Carcinogenesis. 36(6):616-21, 2015.

13. Takenaka M, Saito M, Iwakawa R, Yanaihara N, Saito M, Kato M, Ichikawa H,Shibata T, Yokota J, Okamoto A, Kohno T. Profiling of Actionable Gene Alterations in Ovarian Cancer by Targeted Deep Sequencing. Int J Oncol. 46(6):2389-98, 2015.

総説

1 . 川端麗香, 西山正彦, 新たながん医療の創生を目指して:Trans-OMICS Approach, 癌と化学療法, 45巻3号(3月)総説, in press

2 . Kawabata-Iwakawa R, Bono H, Nishiyama M. Next generation sequencing and bioinformatics. Ed. Y Takiguchi, Molecular Targeted Therapy of Lung Cancer, Singapore, Springer Nature Singapore Pte. Ltd, 2017, pp97-116.

学会発表

1 . Yokobori T, Handa T, Kawabata R, Yamane A, Yoshiyama S, Katayama A, Rokudai S, Oyama T, Nishiyama M. Identification of Caspase-14 as one of the new therapeutic targets for triple negative breast cancer patients using shRNA library and next generation sequence. 2016 ASCO Annual Meeting. Chicago, US. 2016. (Poster session)

2 . Kawabata R, Horikoshi I, Yokobori T, Rokudai S, Nishiyama M. RNA-sequencing data analysis suggests that immunotherapy might be a potent treatment option in elderly non-small cell lung cancer patients. ESMO Asia 2015 Congress. Singapore. 2015. (Poster session)

3 . Kawabata-Iwakawa R, I Horikoshi I, Yokobori T, Nishiyama M. Seeds discovery by using whole-transcriptome sequencing: New therapeutic targets identified as specific for elderly non-small cell lung cancer patients. The 3rd International Conference of Federation of Asian Clinical Oncology (FACO). Kyoto, Japan. 2015. (Poster session)

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