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Tumor-Antagonizing Fibroblasts Secrete Prolargin as Tumor Suppressor in Hepatocellular Carcinoma (Dr. Turtoi’s lab and Dr. Yokobori’s lab)

Dr. Andrei Turtoi of GIAR International Open Laboratory “Universities of Liege and Montpellier Lab” PI and Dr. Takehiko Yokobori of GIAR Integrated Oncology Research pressed the research results to elucidated a new mechanism that suppresses the malignancy of liver cancer on bioRxiv, preprint server for biology.

 

Title: Tumor-Antagonizing Fibroblasts Secrete Prolargin as Tumor Suppressor in Hepatocellular Carcinoma

 

Barbara Chiavarina1,2,3, Roberto Ronca4, Yukihiro Otaka5,6, Roger Bryan Sutton7,

Sara Rezzola4, Takehiko Yokobori6,8, Paola Chiodelli4, Regis Souche1,2,3, Antonio Maraver2,3,9,, Gavino Faa10, Tetsunari Oyama11, Stephanie Gofflot12, Akeila Bellahcène13, Olivier Detry14,

Philip Delvenne15, Vincent Castronovo13, Masahiko Nishiyama5,6, Andrei Turtoi1,2,3,6

 

1Tumor Microenvironment and Resistance to Treatment Lab, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Montpellier, France

2 Université de Montpellier, Montpellier, France

3 Institut régional du Cancer de Montpellier (ICM)-Val d’Aurelle, Montpellier, France

4University of Brescia, Department of Molecular and Translational Medicine, Brescia, Italy

5Department of Molecular Pharmacology and Oncology, Gunma University Graduate School of Medicine, Gunma, Japan

6Gunma University Initiative for Advanced Research (GIAR), Maebashi, Gunma, Japan

7Department of Cell Physiology and Molecular Biophysics, Texas Tech University Health Sciences Center, Lubbock, TX, 79430, USA

8Department of General Surgical Science, Graduate School of Medicine, Gunma University Maebashi, Gunma, Japan

9Oncogenic Pathways in Lung Cancer Lab, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Montpellier, France

10Department of Pathology, University Hospital San Giovanni di Dio AOU of Cagliari, University of Cagliari, Cagliari, Italy

11Department of Diagnostic Pathology, Gunma University, Graduate School of Medicine, Maebashi, Gunma, Japan

12BIOTHEQUE, University of Liege, Liege, Belgium

13Metastasis Research Laboratory, GIGA Cancer, University of Liège, Liège, Belgium

14Department of Abdominal Surgery, University Hospital, University of Liège, Liège, Belgium

15Department of Pathology, University Hospital, University of Liège, Liège, Belgium

 

Link:

https://www.biorxiv.org/content/10.1101/2021.01.04.425182v1

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