- Division of Integrated Oncology Research - - Division of Endocrinology, Metabolism and Signal Research - - Division of Element-Function Chemistry - - International Open Laboratory -
Gunma University

Division of Element-Function Chemistry


Md. Zakir Hossain
Position: Professor



1.Synthesis and characterization of 2D materials.
2.Chemical modification of 2D materials.
3.Field Effect Transistor (FET) based biosensors.


1.Graphene: Single layer carbon (C) materials, where the C atoms are arranged in honeycomb lattice. It can be regarded as single  layer of graphite. Graphene has the potential to revolutionize in the fields of electricity, conductivity, energy, batteries, sensors,           medical diagnostic, coating and more.

2.Black Phosphorus: Black Phosphorus is a layered semiconducting material similar in appearance to graphite. Numerous applications in optoelectronic, semiconductor, and photovoltaic are expected. In a two-dimensional (2D) form, black phosphorus is known as Phosphorene.

3.Graphene Field Effect Transistor (GFET): The field-effect transistor (FET) is a type of transistor which uses an electric field to control the flow of current. FETs are devices with three terminals: source, gate, and drain. In GFET, graphene acts as conducting channel.

Two-dimensional (2D) materials are substances with a thickness of a few nanometres or less. Because of some extraordinary physical and chemical properties, 2D materials drawn much interest among the research community as the materials for next generation technology. To date, several hundred of different 2D materials including graphene, black phosphorous, silicone, germanene, h-BN, MXenes, etc. The 2D materials can show the properties of semiconductor, metal, semimetal, or superconductors. Along with the continued exploration of 2D materials, the need for synthesis/growth, characterization, and sensing application is highly desirable. Our laboratory focuses on the synthesis and characterization of graphene and black phosphorus followed by chemical functionalization. Using varieties of organic and inorganic approaches, these 2D materials are functionalized with varies of functional groups such as oxides, halide, hydrocarbons, thiol, metal nanoparticles, etc. For realization of practical application of 2D materials, we also work on fabrication and characterization of GFET focusing on biosensors and bioelectronics.

Representative Works

Shin-ichiro Kato; Ryo Kumagai; Tsukasa Abe; Chisa Higuchi; Yoshihito Shiota; Kazunari Yoshizawa; Nobutaka Takahashi; ji Yamamoto; Md Zakir Hossain*; Kazuhiro Hayashi; Takashi Hirose; Yosuke Nakamura - “Arylene–hexaynylene and –octaynylene macrocycles: extending the polyyne chains drives self-association by enhanced dispersion force”, chemical communication. 2021.

Wang, SY; Hossain, MZ*; Han, T; Shinozuka, K; Suzuki, T; Kuwana, A; Kobayashi, H - “Avidin-Biotin Technology in Gold Nanoparticle-Decorated Graphene Field Effect Transistors for Detection of Biotinylated Macromolecules with Ultrahigh Sensitivity and Specificity”, ACS OMEGA, 2020, 5, 46, 30037-30046.

Wang, SY; Hossain, MZ*; Shinozuka, K; Shimizu, N; Kitada, S; Suzuki, T; Ichige, R; Kuwana, A; Kobayashi, H - “Graphene field-effect transistor biosensor for detection of biotin with ultrahigh sensitivity and specificity”, BIOSENSORS & BIOELECTRONICS, 2020, 165.

Shunya Kitada, Natsuhiko Shimizu and Md Zakir Hossain*, Safe and Fast Synthesis of Black Phosphorus and Its Purification, ACS Omega 2020, 5, 20, 11389-11393.

Zakir Hossain*, Natsuhiko Shimizu, Covalent immobilization of gold nanoparticles on graphene, J. Phys. Chem. C 2019, 123, 3512.

Zakir Hossain*, Natsuhiko Shimizu, In-situ Functionalization of Graphene with Reactive End Group Through Amine Diazotization, J. Phys. Chem. C 2017, 217, 25223.

Zakir Hossain*, Hiyama Yoko, M. A. M. Jusoh – ‘Organic functionalization of epitaxial graphene on SiC through direct binding of transient radicals from the reaction mixture’, Chem. Commun. 2016, 52, 14380.

Zakir Hossain*, Maisarah B. A. Razak, Shinya Yoshimoto, Kozo Mukai, Takanori Koitaya, Jun Yoshinobu, Hayato Sone, Sumio Hosaka, Mark C. Hersam- “Aqueous-Phase Oxidation of Epitaxial Graphene on the Silicon Face of SiC(0001)” J. Phys. Chem. C 2014, 118, 1014.

Zakir Hossain, James E. Johns, Kirk H. Bevan, Hunter J. Karmel, Yu Teng Liang, Shinya Yoshimoto, Kozo Mukai, Tatanori Koitaya, Jun Yoshinobu, Maki Kawai, Amanda M. Lear, Larry L. Kesmodel, Steven L. Tait, and Mark C. Hersam – “Chemically homogeneous and thermally reversible oxidation of epitaxial graphene” Nature Chem. 2012, 4, 305.

Zakir Hossain, Michael A. Walsh, and Mark C. Hersam, “Scanning tunneling microscopy, spectroscopy, and nanolithography of epitaxial graphene chemically modified with aryl moieties” J. Am. Chem. Soc. 2010, 132, 15399.

Zakir Hossain*, Hiroyuki S. Kato, and Maki Kawai – “Self-directed chain reaction by small ketones with the dangling bond site on the Si(100)-(2 x 1)-H surface: Acetophenone, a unique example” J. Am. Chem. Soc. 2008, 130, 11518.

Zakir Hossain*, Hiroyuki S. Kato, and M. Kawai, “Competing Forward and Reversed Chain Reactions in 1D Molecular Line Growth on the Si(100)–(2 x 1)–H Surface” J. Am. Chem. Soc. 129, 3328 (2007).

Zakir Hossain*, Hiroyuki S. Kato, and Maki Kawai – “Controlled Fabrication of 1D Molecular Lines across the Dimer Rows on the Si(100)-(2 x 1)-H Surface through the Radical Chain Reaction” J. Am. Chem. Soc. 2005, 127, 15030.

Zakir Hossain, S. Machida, Y. Yamashita, K. Mukai and J. Yoshinobu – “Purely site-specific chemisorption and conformation of trimethylamine on Si(100)c(4 x 2)” J. Am. Chem. Soc. 2003, 125, 9252.

Zakir Hossain, Y. Yamashita, K. Mukai and J. Yoshinobu – “Model for C-defect on Si(100): The dissociative adsorption of single water molecule on two adjacent dimers” Phys. Rev. B 2003, 67, 153307.

Zakir Hossain, T. Kubo, N. Takagi, T. Tsuno, N. Fujimori, T. Ando, T. Aruga and M. Nishijima – “Diels-Alder reaction on the clean diamond(100)(2 x 1) surface” Jpn. J. Appl. Phys1999, 38, L1496.