The hypoxic environment and HIF-1α accumulation in cancer tissues have attracted attention as therapeutic targets because they are involved in resistance to several treatments, including radiation. In this study, we found that administration of the smallest level of oxygen nanobubbles developed by our research group to cancer-bearing mouse models improved radiosensitivity and suppressed HIF-1α expression. Furthermore, it was confirmed that the oxygen nanobubbles did not cause toxicity (organ damage, weight loss, abnormal behavior) in healthy mice. In the future, combining radiation and the oxygen nanobubble water without severe side effects may be a promising treatment option to improve radiosensitivity in cancer patients who cannot tolerate invasive treatments.
■Title
Navchaa Gombodorj 1,2,3,†, Takehiko Yokobori 1,*,†, Nobutoshi Mutsuki 4, Bilguun Erkhem-Ochir 1,5, Haruka Okami 5, Takayuki Asao 6, Hiroshi Saeki 5, Ken Shirabe 5 and, Dai Yamanouchi 7,*
*Authors to whom correspondence should be addressed.†These authors contributed equally to this work.
1 Division of Integrated Oncology Research, Gunma University Initiative for Advanced Research (GIAR), 3-39-22 Showamachi, Maebashi 371-8511, Japan
2 Department of Radiation Oncology, National Cancer Center, Ulaanbaatar 13370, Mongolia
3 Division of Referral and Primary Healthcare Services, Ministry of Health, Ulaanbaatar 14210, Mongolia
4 Sigma Technology Inc., 1-11-29 Sotono, Hitachinaka 312-0053, Japan
5 Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi 371-8510, Japan
6 Gunma University Center for Mathematics and Data Science, 4-2 Aramaki, Maebashi 371-8510, Japan
7 Division of Vascular Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI 53726, USA
■Journal
International Journal of Molecular Sciences (IF 5.542)
DOI 10.3390/ijms23126838 (2022.6.20 published)
■Link
