DNA Repair Studies
How can damaged DNA be repaired?
Unravel the mysteries of DNA repair, the force to accurately restore DNA!
Molecular biology, cancer medicine
DNA repair, fluorescence imaging analysis, cancer therapy, cancer immunotherapy
Actually, the DNA of the human body is damaged at a high rate every day. However, the human body is able to conduct DNA repair, namely to accurately restore damaged DNA. Our laboratory regards DNA repair as a single discipline, and our aim is to contribute to the promotion of human health by eludicating DNA repair mechanisms and applying them to various medical treatments.
We need to know more about this reaction system because whether or not DNA (the blueprint of the human body) can be properly repaired, obviously affects the entire human body. We are trying to elucidate how cells select the best DNA repair pathway and maintain a stable genome. In particular, we are trying to visualize DNA repair in living cells, which was impossible with previous techniques, by taking advantage of new technologies, including super-resolution microscopy.
We are conducting research on how DNA repair reactions that occur during cancer treatment affect the effectiveness of treatment. For example, radiotherapy and chemotherapy, which are performed during cancer treatment, kill cancer cells by damaging their DNA. In other words, we believe that we can contribute to cancer treatment by clarifying how DNA damage that occurs during cancer treatment is repaired or not repaired.
We pursue research every day, believing that the elucidation of mechanisms that are related to DNA repair, which is fundamental for the maintenance of life, will lead to the development of various medical treatments, including cancer therapy.