Akikazu HARADA | Gunma University Initiative for Advanced Research

Brief History

April 2026 – Present	Associate Professor, Division of Gene Therapy Science, Gunma University Initiative for Advanced Research, Gunma University
April 2024 – March 2026	Specially Appointed Professor, Center for Infectious Disease Education and Research (CiDER), The University of Osaka
April 2022 – March 2026	Researcher, Institute for Open and Transdisciplinary Research Initiatives (OTRI), Intergrated Frontier Research for Medical Science Division, The University of Osaka Graduate School of Medicine
April 2022 – March 2024	Assistant Professor, Osaka University Graduate School of Medicine
April 2015 – March 2018	Medical Resident, Sumitomo Hospital

Main Achievements

Papers

Development of ARL4C antisense oligonucleotide with reduced off-target effects and enhanced efficacy as an anti-cancer drug.

Kanae Kawai, Shinji Matsumoto, Akikazu Harada, Ryota Sada, Takeshi Harada, Yuuya Kasahara, Satoshi Obika, Yasushi Okamura, Akira Kikuchi

In vitro cellular & developmental biology. Animal March 6th, 2026 Peer-reviewed paper
Hypoxia-induced Wnt5a-secreting fibroblasts promote colon cancer progression.

Akikazu Harada, Yoshiaki Yasumizu, Takeshi Harada, Katsumi Fumoto, Akira Sato, Natsumi Maehara, Ryota Sada, Shinji Matsumoto, Takashi Nishina, Kiyoshi Takeda …

Nature communications 16(1) 3653-3653 April 17th, 2025 First and corresponding author / Peer-reviewed paper
Hypoxia drives the formation of lung micropapillary adenocarcinoma-like structure through hypoxia-inducible factor-1α

Daisuke Umeda, Akikazu Harada, Daisuke Motooka, Shinichiro Tahara, Masako Kurashige, Kansuke Kido, Tsuyoshi Takashima, Hiroki Kiyokawa, Koto Ukon, Takahiro Matsui …

Scientific Reports 14(1) December 30th, 2024 Peer-reviewed paper
Newly developed humanized anti-CKAP4 antibody suppresses pancreatic cancer growth by inhibiting DKK1-CKAP4 signaling.

Ryota Sada, Hideki Yamamoto, Shinji Matsumoto, Akikazu Harada, Akira Kikuchi

Cancer science August 8th, 2024 Peer-reviewed paper
GREB1 isoform 4 is specifically transcribed by MITF and required for melanoma proliferation.

Koei Shinzawa, Shinji Matsumoto, Ryota Sada, Akikazu Harada, Kaori Saitoh, Keiko Kato, Satsuki Ikeda, Akiyoshi Hirayama, Kazunori Yokoi, Atsushi Tanemura …

Oncogene 42(42) 3142-3156 September 1st 2023 Peer-reviewed paper
Wnt Signaling Stimulates Cooperation between GREB1 and HNF4α to Promote Proliferation in Hepatocellular Carcinoma.

Shinji Matsumoto, Akikazu Harada, Minami Seta, Masayuki Akita, Hidetoshi Gon, Takumi Fukumoto, Akira Kikuchi

Cancer research 83(14) 2312-2327 July 14th, 2023 First-authored /Peer-reviewed paper

Localization of KRAS downstream target ARL4C to invasive pseudopods accelerates pancreatic cancer cell invasion.

Akikazu Harada, Shinji Matsumoto, Yoshiaki Yasumizu, Kensaku Shojima, Toshiyuki Akama, Hidetoshi Eguchi, Akira Kikuchi

eLife 10 September 30th, 2021 First-authored /Peer-reviewed paper
The Dickkopf1 and FOXM1 positive feedback loop promotes tumor growth in pancreatic and esophageal cancers.

Hirokazu Kimura, Ryota Sada, Naoki Takada, Akikazu Harada, Yuichiro Doki, Hidetoshi Eguchi, Hideki Yamamoto, Akira Kikuchi

Oncogene 40(26) 4486-4502 July 2021 Peer-reviewed paper

Members

Brief History

Related Websites

Main Achievements

bn1

bn2

bn3

bn4