Gunma University Initiative for Advanced Research > About GIAR > Members > Division of Integrated Oncology Research > Dr. Yokobori Laboratory > YOKOBORI Takehiko


Brief History

April 2019 – Present Associate Professor, Division of Integrated Oncology Research, Gunma University Initiative for Advanced
Research (GIAR)
August 2018 Specially Appointed Associate Professor, Department of Innovative Cancer Immunotherapy, Gunma University
May 2018 Specially Appointed Associate Professor, Department of Oncology Clinical Development, Gunma University
October 2016 Lecturer at GIAR
April 2015 Lecturer, Molecular Pharmacology and Oncology, Gunma University
April 2013 Assistant Professor, Department of General Pathology and Surgical Science, Gunma University
July 2010 Medical Staff, Department of Surgery, Gunma University Hospital
April 2007 Medical Institute of Bioregulation, Kyushu University (Beppu)
April 2006 Medical Staff, Department of Surgery, Gunma Saiseikai Maebashi Hospital
April 2005 Department of Surgery, Gunma University Hospital
April 2004 Department of Surgery, Fujioka General Hospital, Gunma Prefecture
June 2003 Department of Surgery, Nakatsu Municipal Hospital, Oita Prefecture
May 2002 Pathology and General Surgery, Gunma University Hospital
March 2002 Graduated from St. Marianna University School of Medicine

Main Achievements


  • Yoshida, T; Yokobori, T; Saito, H; Kuriyama, K; Kumakura, Y; Honjo, H; Hara, K; Sakai, M; Miyazaki, T; Obinata, H; Erkhem-Ochir, B; Gombodorj, N; Sohda, M; Saeki, H; Kuwano, H; Shirabe, K CD36 Expression Is Associated with Cancer Aggressiveness and Energy Source in Esophageal Squamous Cell Carcinoma. ANNALS OF SURGICAL ONCOLOGY. 2021 Feb; 28(2): 1217-1227.
  • Bilguun Erkhem-Ochir MD, Wataru Tatsuishi MD,PhD, Takehiko Yokobori MD, PhD,Tsukasa Ohno MD, PhD, KyoheiHatori MD, PhD, Tadashi Handa PhD,Tetsunari Oyama MD, PhD, Ken Shirabe, MD, PhD, Hiroshi Saeki MD,PhD, Tomonobu Abe MD, PhD Inflammatory and immune checkpoint markers are associated with the severity of aortic stenosis. JTCVS. 2021 Jan.
  • Chiavarina, B; Costanza, B; Ronca, R; Blomme, A; Rezzola, S; Chiodelli, P; Giguelay, A; Belthier, G; Doumont, G; Van Simaeys, G; Lacroix, S; Yokobori, T; Erkhem-Ochir, B; Balaguer, P; Cavailles, V; Fabbrizio, E; Di Valentin, E; Gofflot, S; Detry, O; Jerusalem, G; Goldman, S; Delvenne, P; Bellahcene, A; Pannequin, J; Castronovo, V; Turtoi, A Metastatic colorectal cancer cells maintain the TGF beta program and use TGFBI to fuel angiogenesis. THERANOSTICS. 2021 Jan; 11(4): 1626-1640.


  • Kuwano, H; Yokobori, T; Kumakura, Y; Ogata, K; Yoshida, T; Kuriyama, K; Sakai, M; Sohda, M; Miyazaki, T; Saeki, H; Shirabe, K Pathophysiology of Vomiting and Esophageal Perforation in Boerhaave’s Syndrome. DIGESTIVE DISEASES AND SCIENCES. 2020. Nov; 65(11): 3253-3259.
  • Dolgormaa, G; Harimoto, N; Ishii, N; Yamanaka, T; Hagiwara, K; Tsukagoshi, M; Igarashi, T; Watanabe, A; Kubo, N; Araki, K; Handa, T; Yokobori, T; Oyama, T; Kuwano, H; Shirabe, K Mac-2-binding protein glycan isomer enhances the aggressiveness of hepatocellular carcinoma by activating mTOR signaling. BRITISH JOURNAL OF CANCER. 2020 Sep 29; 123(7): 1145-1153.
  • Kubo, N; Yokobori, T; Takahashi, R; Ogawa, H; Gombodorj, N; Ohta, N; Ohno, T; Saeki, H; Shirabe, K; Asao, T An abdominal spacer that does not require surgical removal and allows drainage of abdominal fluids in patients undergoing carbon ion radiotherapy. PLOS ONE. 2020 Jun 10; 15(6): e0234471.
  • Kuriyama, K; Higuchi, T; Yokobori, T; Saito, H; Yoshida, T; Hara, K; Suzuki, S; Sakai, M; Sohda, M; Higuchi, T; Tsushima, Y; Asao, T; Kaira, K; Kuwano, H; Shirabe, K; Saeki, H Uptake of positron emission tomography tracers reflects the tumor immune status in esophageal squamous cell carcinoma. CANCER SCIENCE. 2020 Jun; 111(6): 1969-1978.
  • Baatar, S; Bai, T; Yokobori, T; Gombodorj, N; Nakazawa, N; Ubukata, Y; Kimura, A; Kogure, N; Sano, A; Sohda, M; Sakai, M; Tumenjargal, A; Ogata, K; Kuwano, H; Shirabe, K; Saeki, H High RAD18 Expression is Associated with Disease Progression and Poor Prognosis in Patients with Gastric Cancer. ANNALS OF SURGICAL ONCOLOGY. 2020 Oct; 27(11): 4360-4368.
  • Togo, M; Yokobori, T; Shimizu, K; Handa, T; Kaira, K; Sano, T; Tsukagoshi, M; Higuchi, T; Yokoo, S; Shirabe, K; Oyama, T Diagnostic value of F-18-FDG-PET to predict the tumour immune status defined by tumoural PD-L1 and CD8(+)tumour-infiltrating lymphocytes in oral squamous cell carcinoma. BRITISH JOURNAL OF CANCER. 2020 May 26; 122(11): 1686-1694.
  • Hagiwara, K; Harimoto, N; Yokobori, T; Muranushi, R; Hoshino, K; Gantumur, D; Yamanaka, T; Ishii, N; Tsukagoshi, M; Igarashi, T; Tanaka, H; Watanabe, A; Kubo, N; Araki, K; Hosouchi, Y; Shirabe, K High Co-expression of Large Tenascin C Splice Variants in Stromal Tissue and Annexin A2 in Cancer Cell Membranes is Associated with Poor Prognosis in Pancreatic Cancer. ANNALS OF SURGICAL ONCOLOGY. 2020 Mar; 27(3): 924-930.
  • Yamanaka, T; Harimoto, N; Yokobori, T; Muranushi, R; Hoshino, K; Hagiwara, K; Gantumur, D; Handa, T; Ishii, N; Tsukagoshi, M; Igarashi, T; Tanaka, H; Watanabe, A; Kubo, N; Araki, K; Shirabe, K Nintedanib inhibits intrahepatic cholangiocarcinoma aggressiveness via suppression of cytokines extracted from activated cancer-associated fibroblasts. BRITISH JOURNAL OF CANCER. 2020 Mar; 122(7): 986-994.


Shimizu K, Goto Y, Kawabata-Iwakawa R, Ohtaki Y, Nakazawa S, Yokobori T, Obayashi K, Kawatani N, Yajima T, Kaira K, Mogi A, Hirato J, Nishiyama M, Shirabe K. Stathmin-1 is a useful diagnostic marker for high-grade lung neuroendocrine tumors. Ann Thorac Surg. 2019 Mar 22. pii: S0003-4975(19)30392-3.


Suzuki K, Watanabe A, Araki K, Yokobori T, Harimoto N, Gantumur D, Hagiwara K, Yamanaka T, Ishii N, Tsukagoshi M, Igarashi T, Kubo N, Gombodorj N, Nishiyama M, Hosouchi Y, Kuwano H, Shirabe K. High STMN1 Expression Is Associated with Tumor Differentiation and Metastasis in Clinical Patients with Pancreatic Cancer. Anticancer Res. 2018 Feb;38(2):939-944.


  • Bao P, Yokobori T, Altan B, Iijima M, Azuma Y, Onozato R, Yajima T, Watanabe A, Mogi A, Shimizu K, Nagashima T, Ohtaki Y, Obayashi K, Nakazawa S, Bai T, Kawabata-Iwakawa R, Asao T, Kaira K, Nishiyama M, Kuwano H. High STMN1 Expression is Associated with Cancer Progression and Chemo-Resistance in Lung Squamous Cell Carcinoma. Ann Surg Oncol. 2017 Dec;24(13):4017-4024.
  • Obayashi S, Horiguchi J, Higuchi T, Katayama A, Handa T, Altan B, Bai T, Bao P, Bao H, Yokobori T, Nishiyama M, Oyama T, Kuwano H. Stathmin1 expression is associated with aggressive phenotypes and cancer stem cell marker expression in breast cancer patients. Int J Oncol. 2017 Sep;51(3):781-790.
  • Shimizu K, Ohtaki Y, Altan B, Yokobori T, Nagashima T, Arai M, Mogi A, Kuwano H. Prognostic impact of stathmin 1 expression in patients with lung adenocarcinoma. J Thorac Cardiovasc Surg. 2017 Oct;154(4):1406-1417.e3.
  • Watanabe A, Araki K, Yokobori T, Altan B, Ishii N, Tsukagoshi M, Kubo N, Saito F, Suzuki H, Kuwano H. Stathmin 1 promotes the proliferation and malignant transformation of pancreatic intraductal papillary mucinous neoplasms. Oncol Lett. 2017 Mar;13(3):1783-1788.
  • Suzuki S, Yokobori T, Altan B, Hara K, Ozawa D, Tanaka N, Sakai M, Sano A, Sohda M, Bao H, Fukuchi M, Miyazaki T, Kaira K, Asao T, Kuwano H. High stathmin 1 expression is associated with poor prognosis and chemoradiation resistance in esophageal squamous cell carcinoma. Int J Oncol. 2017 Mar 7.
  • Bai T, Yokobori T, Altan B, Ide M, Mochiki E, Yanai M, Kimura A, Kogure N, Yanoma T, Suzuki M, Bao P, Kaira K, Asao T, Katayama A, Handa T, Gombodorj N, Nishiyama M, Oyama T, Ogata K, Kuwano H. High STMN1 level is associated with chemo-resistance and poor prognosis in gastric cancer patients. Br J Cancer. 2017 Apr 25;116(9):1177-1185.


Saito F, Araki K, Yokobori T, Ishii N, Tsukagoshi M, Watanabe A, Kubo N, Altan B, Shirabe K, Kuwano H. High expression of karyopherin-α2 and stathmin 1 is associated with proliferation potency and transformation in the bile duct and gall bladder epithelia in the cases of pancreaticobiliary maljunction. J Surg Oncol. 2016 Sep;114(4):462-8.


Watanabe A, Suzuki H, Yokobori T, Tsukagoshi M, Altan B, Kubo N, Suzuki S, Araki K, Wada S, Kashiwabara K, Hosouchi Y, Kuwano H. Stathmin1 regulates p27 expression, proliferation and drug resistance, resulting in poor clinical prognosis in cholangiocarcinoma. Cancer Sci. 2014 Jun;105(6):690-6.


2018 Grant-in-Aid for Scientific Research by the Pancreas Research Foundation of Japan(Fiscal year 2018)
2018 Fiscal year 2018 Grant-in-Aid by the Suzuken Memorial Foundation
2018 The Eiichiro Tahara Award at the 7th Annual Meeting of the Japanese Society for Gastroenterological Carcinogenesis
2018 2018 Annual Meeting of Chinese Society of Clinical Oncology, Travel grant.
2017 Incentive Award at the 26th Annual Meeting of the Japanese Society of Strategies for Cancer Research and Therapy
2015 Medical Research Encouragement Prize of The Japan Medical Association
2014 Uehara Memorial Foundation Life Science Research Grant
2014 Japan Surgical Society (JSS) Clinical Investigation Project Award
2010 The 7th International Symposium on Cancer Research and Therapy, Subsidy Award