{"id":2991,"date":"2025-12-12T17:46:21","date_gmt":"2025-12-12T08:46:21","guid":{"rendered":"https:\/\/www.giar.gunma-u.ac.jp\/eng\/?p=2991"},"modified":"2025-12-12T17:46:34","modified_gmt":"2025-12-12T08:46:34","slug":"development-of-a-synthetic-lethality-based-combination-therapy-using-lig1-and-parp-inhibitors-for-prostate-cancer","status":"publish","type":"post","link":"https:\/\/www.giar.gunma-u.ac.jp\/eng\/development-of-a-synthetic-lethality-based-combination-therapy-using-lig1-and-parp-inhibitors-for-prostate-cancer\/","title":{"rendered":"Development of a Synthetic Lethality-Based Combination Therapy Using LIG1 and PARP Inhibitors for Prostate Cancer (Division of Gene Therapy Science, Dr. Nimura Laboratory)"},"content":{"rendered":"<p>A collaborative research team consisting of Professor Keisuke Nimura of the Division of Gene Therapy Science, GIAR at Gunma University, together with Lecturer Koji Hatano and graduate student Masaru Tani from the Department of Urology, The University of Osaka Graduate School of Medicine, has advanced research on combination therapies that leverage the mechanism of synthetic lethality, with the aim of developing new treatment strategies for prostate cancer.<\/p>\n<p>In this study, the team searched for molecules that enhance the efficacy of PARP inhibitors and discovered that suppressing LIG1 strengthens therapeutic effects. The combination with an LIG1 inhibitor was shown to have the potential to inhibit tumor growth, offering promise as a new treatment option for prostate cancer.<\/p>\n<p>\u25a0Title<br \/>\n<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cas.70194\" target=\"_blank\" rel=\"noopener\">Development of a Synthetic Lethality-Based Combination Therapy Using LIG1 and PARP Inhibitors for Prostate Cancer<br \/>\n<\/a><br \/>\nMasaru Tani<sup>1<\/sup>, Koji Hatano<sup>1,\uff0a<\/sup>, Yu Ishizuya<sup>1<\/sup>, Toshiki Oka<sup>1<\/sup>, Tomohiro Kanaki<sup>1<\/sup>, Shunsuke Inoguchi<sup>1<\/sup>, Akihiro Yoshimura<sup>1<\/sup>, Yuki Horibe<sup>1<\/sup>, Yutong Liu<sup>1<\/sup>, Sassi Nesrine<sup>1<\/sup>, Yohei Okuda<sup>1<\/sup>, Akinaru Yamamoto<sup>1<\/sup>, Toshihiro Uemura<sup>1<\/sup>, Gaku Yamamichi<sup>1<\/sup>, Takuji Hayashi<sup>1<\/sup>, Yoshiyuki Yamamoto<sup>1<\/sup>, Taigo Kato<sup>1<\/sup>, Atsunari Kawashima<sup>1<\/sup>, Takao Yamaguchi<sup>2<\/sup>, Satoshi Obika<sup>2<\/sup>, Kosuke Yusa<sup>3<\/sup>, Norio Nonomura<sup>1<\/sup>, <strong>Keisuke Nimura<\/strong><sup>4,\uff0a<\/sup><br \/>\n<span style=\"font-size: 10pt;\"><sup>\uff0a<\/sup>corresponding authors<\/span><br \/>\n<span style=\"font-size: 8pt;\">1\u3000Department of Urology, The University of Osaka Graduate School of Medicine, Suita, Japan<\/span><br \/>\n<span style=\"font-size: 8pt;\">2\u3000Graduate School of Pharmaceutical Sciences, The Universityof Osaka, Suita, Japan<\/span><br \/>\n<span style=\"font-size: 8pt;\">3\u3000Stem Cell Genetics, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan<\/span><br \/>\n<span style=\"font-size: 8pt;\">4\u3000Division of Gene Therapy Science,Gunma University Initiative for Advanced Research, Gunma University, Maebashi, Japan <\/span><\/p>\n<p>\u25a0Journal<br \/>\nCancer Science\u3000(IF: 4.3)<br \/>\nDOI\u3000<a href=\"https:\/\/doi.org\/10.1111\/cas.70194\" target=\"_blank\" rel=\"noopener\"><span>10.1111\/cas.70194<\/span><\/a><\/p>\n<p>\u25a0Link<br \/>\n<a href=\"https:\/\/www.giar.gunma-u.ac.jp\/eng\/laboratory\/gene-therapy-science\/dr-nimura-laboratory\/\" target=\"_blank\" rel=\"noopener\">Dr.NIMURA Laboratory<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A collaborative research team consisting of Professor Keisuke Nimura of the Division of Gene Therapy Science,  [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[17],"tags":[],"class_list":["post-2991","post","type-post","status-publish","format-standard","hentry","category-research"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.giar.gunma-u.ac.jp\/eng\/wp-json\/wp\/v2\/posts\/2991","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.giar.gunma-u.ac.jp\/eng\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.giar.gunma-u.ac.jp\/eng\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.giar.gunma-u.ac.jp\/eng\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.giar.gunma-u.ac.jp\/eng\/wp-json\/wp\/v2\/comments?post=2991"}],"version-history":[{"count":5,"href":"https:\/\/www.giar.gunma-u.ac.jp\/eng\/wp-json\/wp\/v2\/posts\/2991\/revisions"}],"predecessor-version":[{"id":3002,"href":"https:\/\/www.giar.gunma-u.ac.jp\/eng\/wp-json\/wp\/v2\/posts\/2991\/revisions\/3002"}],"wp:attachment":[{"href":"https:\/\/www.giar.gunma-u.ac.jp\/eng\/wp-json\/wp\/v2\/media?parent=2991"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.giar.gunma-u.ac.jp\/eng\/wp-json\/wp\/v2\/categories?post=2991"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.giar.gunma-u.ac.jp\/eng\/wp-json\/wp\/v2\/tags?post=2991"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}