採用情報
ラボラトリー
【統合腫瘍学研究部門】
【内分泌代謝・シグナル学研究部門】
【元素科学研究部門】
【海外ラボラトリー】
国立大学法人 群馬大学
JREC-IN

 統合腫瘍学研究部門

川端研究室

川端 麗香
職名:講師

業績

<論文>

1. Ohtaki Y, Shimizu K, Kawabata-Iwakawa R, Gombodorj N, Altan B, Rokudai S, Yamane A, Kaira K, Yokobori T, Nagashima T, Obayashi K, Nakazawa S, Iijima M, Kosaka T, Yajima T, Mogi A, Kuwano H, Shirabe K, Nishiyama M. Carbonic anhydrase 9 expression is associated with poor prognosis, tumor proliferation, and radiosensitivity of thymic carcinomas. Oncotarget. 10(13):1306-1319, 2019.

2. Handa T, Katayama A, Yokobori T, Yamane A, Fujii T, Obayashi S, Kurozumi S, Kawabata-Iwakawa R, Gombodorj N, Nishiyama M, Asao T, Shirabe K, Kuwano H, Oyama T. Carboxypeptidase A4 accumulation is associated with an aggressive phenotype and poor prognosis in triple-negative breast cancer. Int J Oncol. 54(3):833-844, 2019.

3. Bao P, Yokobori T, Altan B, Iijima M, Azuma Y, Onozato R, Yajima T, Watanabe A, Mogi A, Shimizu K, Nagashima T, Ohtaki Y, Obayashi K, Nakazawa S, Bai T, Kawabata-Iwakawa R, Asao T, Kaira K, Nishiyama M, Kuwano H. High STMN1 Expression is Associated with Cancer Progression and Chemo-Resistance in Lung Squamous Cell Carcinoma. Ann Surg Oncol. 2017 Dec;24(13):4017-4024.

4. Sundaresan V, Lin VT, Liang F, Kaye FJ, Kawabata-Iwakawa R, Shiraishi K, Kohno T,Yokota J, Zhou L. Significantly mutated genes and regulatory pathways in SCLC-a meta-analysis. Cancer Genetics, 216-217: 20-28, 2017.

5. Handa T, Katayama A, Yokobori T, Yamane A, Horiguchi J, Kawabata-Iwakawa R,Rokudai S, Bao P, Gombodorj N, Altan B, Kaira K, Asao T, Kuwano H, Nishiyama M, Oyama T. Caspase14 expression is associated with triple negative phenotypes and cancer stem cell marker expression in breast cancer patients. J Surg Oncol. In press, 2017.

6. Gombodorj N, Yokobori T, Yoshiyama S, Kawabata-Iwakawa R, Rokudai S, Horikoshi I, Nishiyama M, Nakano T. Inhibition of Ubiquitin-conjugating Enzyme E2 May Activate the Degradation of Hypoxia-inducible Factors and, thus, Overcome Cellular Resistance to Radiation in Colorectal Cancer. Anticancer Res. 37(5):2425-2436, 2017.

7. Otaka Y, Rokudai S, Kaira K, Fujieda M, Horikoshi I, Iwakawa-Kawabata R, Yoshiyama S, Yokobori T, Ohtaki Y, Shimizu K, Oyama T, Tamura J, Prives C, Nishiyama M. STXBP4 drives tumor growth and is associated with poor prognosis through PDGF Receptor signaling in lung squamous cell carcinoma. Clinical Cancer Research. 23(13):3442-3452, 2017.

8. Arai H, Nobusawa S, Kawabata-Iwakawa R, Rokudai S, Higuchi T, Yamazaki T, Horiguchi J, Sano T, Kojima M, Nishiyama M, Yokoo H, Hirato J, Oyama T. Myeloid sarcoma arising in malignant phyllodes tumour: clonal relationships revealed by comparative genome-wide analyses. Br J Haematol. in press, 2017.

9. George J, Saito M, Tsuta K, Iwakawa R, Shiraishi K, Scheel A, Uchida S, Watanabe SI, Nishikawa R, Noguchi M, Peifer M, Petersen I, Jang SJ, Buttners R, Harris CC, Yokota J, Thomas RK, Kohno T. Genomic amplification of CD274 (PD-L1) in small cell lung cancer. Clin Cancer Res. 23(5):1220-1226, 2017.

10. Tsuboi M, Yamane A, Horiguchi J, Yokobori T, Kawabata-Iwakawa R, Yoshiyama S, Rokudai S, Odawara H, Tokiniwa H, Oyama T, Takeyoshi I, Nishiyama M. APOBEC3B high expression status is associated with aggressive phenotype in Japanese breast cancers. Breast Cancer. 23(5):780-8, 2016.

11. Takahashi H, Sakakura K, Kawabata-Iwakawa R, Rokudai S, Toyoda M, Nishiyama M,Chikamatsu K. Immunosuppressive activity of cancer-associated fibroblasts in head and neck squamous cell carcinoma. Cancer Immunol Immunother. 64(11):1407-17, 2015.

12. Simo-Riudalbas L, Perez-Salvia M, Setien F, Villanueva A, Moutinho C, Martinez-Cardus A, Moran S, Berdasco M, Gomez A, Vidal E, Soler M, Heyn H, Vaquero A, de la Torre C, Barcelo-Batllori S, Vidal A, Roz L, Pastorino U, Szakszon K, Borck G, Moura C, Carneiro F, Zondervan I, Savola S, Iwakawa R, Kohno T, Yokota J, Esteller M. KAT6B is a tumor suppressor histone H3 lysine 23 acetyltransferase undergoing genomic loss in small cell lung cancer. Cancer Res. 75(18):3936-45, 2015.

13. George J, Lim JS, Jang SJ, Cun Y, Ozretić L, Kong G, Leenders F, Lu X, Fernàndez-Cuesta L, Bosco G, Müller C, Dahmen I, Jahchan NS, Park KS, Yang D, Karnezis AN, Vaka D, Torres A, Wang MS, Korbel JO, Menon R, Chun SM, Kim D, Wilkerson M, Hayes N, Engelmann D, Pützer B, Bos M, Michels S, Vlasic I, Seidel D, Pinther B, Schaub P, Becker C, Altmüller J, Yokota J, Kohno T, Iwakawa R, Tsuta K, Noguchi M, Muley T, Hoffmann H, Schnabel PA, Petersen I, Chen Y, Soltermann A, Tischler V, Choi CM, Kim YH, Massion PP, Zou Y, Jovanovic D, Kontic M, Wright GM, Russell PA, Solomon B, Koch I, Lindner M, Muscarella LA, la Torre A, Field JK, Jakopovic M, Knezevic J, Castaños-Vèlez E, Roz L, Pastorino U, Brustugun OT, Lund-Iversen M, Thunnissen E, Köhler J, Schuler M, Botling J, Sandelin M, Sanchez-Cespedes M, Salvesen HB, Achter V, Lang U, Bogus M, Schneider PM, Zander T, Ansèn S, Hallek M, Wolf J, Vingron M, Yatabe Y, Travis WD, Nürnberg P, Reinhardt C, Perner S, Heukamp L, Büttner R, Haas SA, Brambilla E, Peifer M, Sage J, Thomas RK. Comprehensive genomic profiles of small cell lung cancer. Nature. 524(7563):47-53,
2015.

14. Iwakawa R, Kohno T, Totoki Y, Shibata T, Tsuchihara K, Mimaki S, Tsuta K, Narita Y, Nishikawa R, Noguchi M, Harris C, Robles A, Yamaguchi R, Imoto S, Miyano S, Totsuka H, Yoshida T, Yokota J. Expression and Clinical Significance of Genes Frequently Mutated in Small Cell Lung Cancers Defined by Whole Exome/RNA Sequencing. Carcinogenesis. 36(6):616-21, 2015.

15. Takenaka M, Saito M, Iwakawa R, Yanaihara N, Saito M, Kato M, Ichikawa H,Shibata T, Yokota J, Okamoto A, Kohno T. Profiling of Actionable Gene Alterations in Ovarian Cancer by Targeted Deep Sequencing. Int J Oncol. 46(6):2389-98, 2015.

総説

1. 川端麗香, 西山正彦, 新たながん医療の創生を目指して:Trans-OMICS Approach, 癌と化学療法, 45巻3号(3月)総説, in press

2. Kawabata-Iwakawa R, Bono H, Nishiyama M. Next generation sequencing and bioinformatics. Ed. Y Takiguchi, Molecular Targeted Therapy of Lung Cancer, Singapore, Springer Nature Singapore Pte. Ltd, 2017, pp97-116.

学会発表

1. Kawabata R, Turtoi A, Yokobori T, Nishiyama M, et al., Myoferlin as an important crew in lipid metabolism and progression of colon cancer liver metastasis, The 9th International Conference of the International Society of Gastroenterological Carcinogenesis (ISGC), Kumamoto, Japan, 2017. (Symposium)

2. Kawabata R, Nishiyama M, Heading towards clinical implementation of omics-based medicine, The 4th International Symposium of Gunma University Initiative for Advanced Research (GIAR), Gunma, Japan, 2017. (Symposium)

3 . Yokobori T, Handa T, Kawabata R, Yamane A, Yoshiyama S, Katayama A, Rokudai S, Oyama T, Nishiyama M. Identification of Caspase-14 as one of the new therapeutic targets for triple negative breast cancer patients using shRNA library and next generation sequence. 2016 ASCO Annual Meeting. Chicago, US. 2016. (Poster session)

4 . Kawabata R, Horikoshi I, Yokobori T, Rokudai S, Nishiyama M. RNA-sequencing data analysis suggests that immunotherapy might be a potent treatment option in elderly non-small cell lung cancer patients. ESMO Asia 2015 Congress. Singapore. 2015. (Poster session)

5 . Kawabata-Iwakawa R, I Horikoshi I, Yokobori T, Nishiyama M. Seeds discovery by using whole-transcriptome sequencing: New therapeutic targets identified as specific for elderly non-small cell lung cancer patients. The 3rd International Conference of Federation of Asian Clinical Oncology (FACO). Kyoto, Japan. 2015. (Poster session)

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