採用情報
ラボラトリー
【統合腫瘍学研究部門】
【内分泌代謝・シグナル学研究部門】
【元素科学研究部門】
【海外ラボラトリー】
国立大学法人 群馬大学
JREC-IN

統合腫瘍学研究部門

横堀研究室

横堀 武彦
職名:准教授

研究テーマ

Cancer biomarker, immunotherapy, molecular target

主要業績

論文

~2021~

Yoshida, T; Yokobori, T; Saito, H; Kuriyama, K; Kumakura, Y; Honjo, H; Hara, K; Sakai, M; Miyazaki, T; Obinata, H; Erkhem-Ochir, B; Gombodorj, N; Sohda, M; Saeki, H; Kuwano, H; Shirabe, K  CD36 Expression Is Associated with Cancer Aggressiveness and Energy Source in Esophageal Squamous Cell Carcinoma. ANNALS OF SURGICAL ONCOLOGY. 2021 Feb; 28(2): 1217-1227.

 

Bilguun Erkhem-Ochir MD, Wataru Tatsuishi MD,PhD, Takehiko Yokobori MD, PhD,Tsukasa Ohno MD, PhD, KyoheiHatori MD, PhD, Tadashi Handa PhD,Tetsunari Oyama MD, PhD, Ken Shirabe, MD, PhD, Hiroshi Saeki MD,PhD, Tomonobu Abe MD, PhD  Inflammatory and immune checkpoint markers are associated with the severity of aortic stenosis. JTCVS. 2021 Jan.

 

Chiavarina, B; Costanza, B; Ronca, R; Blomme, A; Rezzola, S; Chiodelli, P; Giguelay, A; Belthier, G; Doumont, G; Van Simaeys, G; Lacroix, S; Yokobori, T; Erkhem-Ochir, B; Balaguer, P; Cavailles, V; Fabbrizio, E; Di Valentin, E; Gofflot, S; Detry, O; Jerusalem, G; Goldman, S; Delvenne, P; Bellahcene, A; Pannequin, J; Castronovo, V; Turtoi, A  Metastatic colorectal cancer cells maintain the TGF beta program and use TGFBI to fuel angiogenesis. THERANOSTICS. 2021 Jan; 11(4): 1626-1640.

 

~2020~

Kuwano, H; Yokobori, T; Kumakura, Y; Ogata, K; Yoshida, T; Kuriyama, K; Sakai, M; Sohda, M; Miyazaki, T; Saeki, H; Shirabe, K  Pathophysiology of Vomiting and Esophageal Perforation in Boerhaave’s Syndrome. DIGESTIVE DISEASES AND SCIENCES. 2020. Nov; 65(11): 3253-3259.

 

Dolgormaa, G; Harimoto, N; Ishii, N; Yamanaka, T; Hagiwara, K; Tsukagoshi, M; Igarashi, T; Watanabe, A; Kubo, N; Araki, K; Handa, T; Yokobori, T; Oyama, T; Kuwano, H; Shirabe, K  Mac-2-binding protein glycan isomer enhances the aggressiveness of hepatocellular carcinoma by activating mTOR signaling. BRITISH JOURNAL OF CANCER. 2020 Sep 29; 123(7): 1145-1153.

 

Kubo, N; Yokobori, T; Takahashi, R; Ogawa, H; Gombodorj, N; Ohta, N; Ohno, T; Saeki, H; Shirabe, K; Asao, T  An abdominal spacer that does not require surgical removal and allows drainage of abdominal fluids in patients undergoing carbon ion radiotherapy. PLOS ONE. 2020 Jun 10; 15(6): e0234471.

 

Kuriyama, K; Higuchi, T; Yokobori, T; Saito, H; Yoshida, T; Hara, K; Suzuki, S; Sakai, M; Sohda, M; Higuchi, T; Tsushima, Y; Asao, T; Kaira, K; Kuwano, H; Shirabe, K; Saeki, H  Uptake of positron emission tomography tracers reflects the tumor immune status in esophageal squamous cell carcinoma. CANCER SCIENCE. 2020 Jun; 111(6): 1969-1978.

 

Baatar, S; Bai, T; Yokobori, T; Gombodorj, N; Nakazawa, N; Ubukata, Y; Kimura, A; Kogure, N; Sano, A; Sohda, M; Sakai, M; Tumenjargal, A; Ogata, K; Kuwano, H; Shirabe, K; Saeki, H  High RAD18 Expression is Associated with Disease Progression and Poor Prognosis in Patients with Gastric Cancer. ANNALS OF SURGICAL ONCOLOGY. 2020 Oct; 27(11): 4360-4368.

 

Togo, M; Yokobori, T; Shimizu, K; Handa, T; Kaira, K; Sano, T; Tsukagoshi, M; Higuchi, T; Yokoo, S; Shirabe, K; Oyama, T  Diagnostic value of F-18-FDG-PET to predict the tumour immune status defined by tumoural PD-L1 and CD8(+)tumour-infiltrating lymphocytes in oral squamous cell carcinoma. BRITISH JOURNAL OF CANCER. 2020 May 26; 122(11): 1686-1694.

 

Hagiwara, K; Harimoto, N; Yokobori, T; Muranushi, R; Hoshino, K; Gantumur, D; Yamanaka, T; Ishii, N; Tsukagoshi, M; Igarashi, T; Tanaka, H; Watanabe, A; Kubo, N; Araki, K; Hosouchi, Y; Shirabe, K  High Co-expression of Large Tenascin C Splice Variants in Stromal Tissue and Annexin A2 in Cancer Cell Membranes is Associated with Poor Prognosis in Pancreatic Cancer. ANNALS OF SURGICAL ONCOLOGY. 2020 Mar; 27(3): 924-930.

 

Yamanaka, T; Harimoto, N; Yokobori, T; Muranushi, R; Hoshino, K; Hagiwara, K; Gantumur, D; Handa, T; Ishii, N; Tsukagoshi, M; Igarashi, T; Tanaka, H; Watanabe, A; Kubo, N; Araki, K; Shirabe, K    Nintedanib inhibits intrahepatic cholangiocarcinoma aggressiveness via suppression of cytokines extracted from activated cancer-associated fibroblasts. BRITISH JOURNAL OF CANCER. 2020 Mar; 122(7): 986-994.

 

~2019~

Shimizu K, Goto Y, Kawabata-Iwakawa R, Ohtaki Y, Nakazawa S, Yokobori T, Obayashi K, Kawatani N, Yajima T, Kaira K, Mogi A, Hirato J, Nishiyama M, Shirabe K. Stathmin-1 is a useful diagnostic marker for high-grade lung neuroendocrine tumors. Ann Thorac Surg. 2019 Mar 22. pii: S0003-4975(19)30392-3.

 

~2018~

Suzuki K, Watanabe A, Araki K, Yokobori T, Harimoto N, Gantumur D, Hagiwara K, Yamanaka T, Ishii N, Tsukagoshi M, Igarashi T, Kubo N, Gombodorj N, Nishiyama M, Hosouchi Y, Kuwano H, Shirabe K. High STMN1 Expression Is Associated with Tumor Differentiation and Metastasis in Clinical Patients with Pancreatic Cancer. Anticancer Res. 2018 Feb;38(2):939-944.

 

~2017~

Bao P, Yokobori T, Altan B, Iijima M, Azuma Y, Onozato R, Yajima T, Watanabe A, Mogi A, Shimizu K, Nagashima T, Ohtaki Y, Obayashi K, Nakazawa S, Bai T, Kawabata-Iwakawa R, Asao T, Kaira K, Nishiyama M, Kuwano H. High STMN1 Expression is Associated with Cancer Progression and Chemo-Resistance in Lung Squamous Cell Carcinoma. Ann Surg Oncol. 2017 Dec;24(13):4017-4024.

 

Obayashi S, Horiguchi J, Higuchi T, Katayama A, Handa T, Altan B, Bai T, Bao P, Bao H, Yokobori T, Nishiyama M, Oyama T, Kuwano H. Stathmin1 expression is associated with aggressive phenotypes and cancer stem cell marker expression in breast cancer patients. Int J Oncol. 2017 Sep;51(3):781-790.

 

Shimizu K, Ohtaki Y, Altan B, Yokobori T, Nagashima T, Arai M, Mogi A, Kuwano H. Prognostic impact of stathmin 1 expression in patients with lung adenocarcinoma. J Thorac Cardiovasc Surg. 2017 Oct;154(4):1406-1417.e3.

 

Watanabe A, Araki K, Yokobori T, Altan B, Ishii N, Tsukagoshi M, Kubo N, Saito F, Suzuki H, Kuwano H. Stathmin 1 promotes the proliferation and malignant transformation of pancreatic intraductal papillary mucinous neoplasms. Oncol Lett. 2017 Mar;13(3):1783-1788.

 

Suzuki S, Yokobori T, Altan B, Hara K, Ozawa D, Tanaka N, Sakai M, Sano A, Sohda M, Bao H, Fukuchi M, Miyazaki T, Kaira K, Asao T, Kuwano H. High stathmin 1 expression is associated with poor prognosis and chemoradiation resistance in esophageal squamous cell carcinoma. Int J Oncol. 2017 Mar 7.

 

Bai T, Yokobori T, Altan B, Ide M, Mochiki E, Yanai M, Kimura A, Kogure N, Yanoma T, Suzuki M, Bao P, Kaira K, Asao T, Katayama A, Handa T, Gombodorj N, Nishiyama M, Oyama T, Ogata K, Kuwano H. High STMN1 level is associated with chemo-resistance and poor prognosis in gastric cancer patients. Br J Cancer. 2017 Apr 25;116(9):1177-1185.

 

~2016~

Saito F, Araki K, Yokobori T, Ishii N, Tsukagoshi M, Watanabe A, Kubo N, Altan B, Shirabe K, Kuwano H. High expression of karyopherin-α2 and stathmin 1 is associated with proliferation potency and transformation in the bile duct and gall bladder epithelia in the cases of pancreaticobiliary maljunction. J Surg Oncol. 2016 Sep;114(4):462-8.

 

~2014~

Watanabe A, Suzuki H, Yokobori T, Tsukagoshi M, Altan B, Kubo N, Suzuki S, Araki K, Wada S, Kashiwabara K, Hosouchi Y, Kuwano H. Stathmin1 regulates p27 expression, proliferation and drug resistance, resulting in poor clinical prognosis in cholangiocarcinoma. Cancer Sci. 2014 Jun;105(6):690-6.

受賞

The 7th International Symposium on Cancer Research and Therapy, Subsidy Award
日本外科学会臨床研究助成
上原記念生命科学財団 研究奨励金
日本医師会 医学研究奨励賞
第26回日本癌病態治療研究会 奨励賞
第7回 日本消化器癌発生学会 田原榮一賞
公益財団法人鈴木謙三記念医科学応用研究財団 平成30年度助成金
日本膵臓病研究財団研究助成金 (平成30年度)
平成30年度高松宮妃癌研究基金研究助成金


Navchaa GombodorjNavchaa Gombodorj
職名:Postdoc researcher

研究テーマ

主要業績

論文

~2019~

Ohtaki Y, Shimizu K, Kawabata-Iwakawa R, Gombodorj N, et al.: Carbonic anhydrase 9 expression is associated with poor prognosis, tumor proliferation, and radiosensitivity of thymic carcinomas. Oncotarget 2019;10:1306-1319.

 

~2018~

Suzuki M, Yokobori T, Gombodorj N, et al.: High stromal transforming growth factor beta-induced expression is a novel marker of progression and poor prognosis in gastric cancer. J Surg Oncol 2018;118:966-974.

 

Gombodorj N, Yokobori T, Tanaka N, et al.: Correlation between high FBXW7 expression in pretreatment biopsy specimens and good response to chemoradiation therapy in patients with locally advanced esophageal cancer: A retrospective study. J Surg Oncol 2018;118:101-108.

 

Gombodorj N, Iijima M, Tachibana Y, et al.: Development of single nanometer-sized ultrafine oxygen bubbles to overcome the hypoxia-induced resistance to radiation therapy via the suppression of hypoxia-inducible factor1alpha. Int J Oncol 2018;52:679-686.

 

Suzuki K, Watanabe A, Araki K, Yokobori T, Gombodorj N, et al.: High STMN1 Expression Is Associated with Tumor Differentiation and Metastasis in Clinical Patients with Pancreatic Cancer. Anticancer Res 2018;38:939-944.

 

~2017~

Handa T, Katayama A, Yokobori T, Gombodorj N, et al.: Caspase14 expression is associated with triple negative phenotypes and cancer stem cell marker expression in breast cancer patients. J Surg Oncol 2017;116:706-715.

 

Gombodorj N, Yokobori T, Yoshiyama S, et al.: Inhibition of Ubiquitin-conjugating Enzyme E2 May Activate the Degradation of Hypoxia-inducible Factors and, thus, Overcome Cellular Resistance to Radiation in Colorectal Cancer. Anticancer Res 2017;37:2425-2436.

 

学会発表

・The 52nd Annual Meeting of the Japan Society of Clinical Oncology (JSCO2014), 2014.8.28-30, Yokohama, Japan: [Ubiquitin Ligase Inhibitor is an Effective Combination Therapy with Radiation in Hypoxic Colorectal Cancer Cells]

・The 73rd Annual Meeting of the Japanese Cancer Association (JCA73), 2014.9.25-27, Yokohama, Japan.

・The 15th International Congress of Radiation Research (ICRR), 2015.5.25-29, Kyoto, Japan.

・The 53rd Annual Meeting of the Japan Society of Clinical Oncology (JSCO2015) and 3rd International Conference of Federation of Asian Clinical Oncology (FACO), 2015.10.29-31, Kyoto, Japan: [Ubiquitin Ligase Inhibitor is an Effective Therapy in Hypoxic Colorectal Cancer Cells]

・The 49th Annual meeting of Japan Research Society for Appropriate Cancer Chemotherapy, 2016.3.25, Aizu Wakamatsu, Fukushima, Japan: [Development of new therapeutics to overcome irradiation resistance induced by hypoxia in colorectal cancer]

・The 49th Annual meeting of Japan Research Society for Appropriate Cancer Chemotherapy, 2016.3.25, Aizu Wakamatsu, Fukushima, Japan: [Development of new therapeutics to overcome irradiation resistance induced by hypoxia in colorectal cancer]

・The 54th Annual Meeting of the Japan Society of Clinical Oncology (JSCO2016), 2016.10.20-22, Yokohama, Japan: [UBE2 inhibitor NSC697923 overcomes HIF-1α-induced radiation resistance in colorectal cancer]

・The 6th International Symposium of Gunma University Program for Leading Graduate Schools International Particle Medicine Research Symposium, 2018.10.30, Takasaki, Gunma, Japan: [Development of a novel radiotherapy sensitizer using the smallest nanobubble technology]

・The 29th Annual meeting of Japanese Society for Gastroenterological Carcinogenesis, 2018.11.16-17, Tokyo, Japan: [Correlation between high FBXW7 expression in pretreatment biopsy and good response to chemoradiation therapy in patients with advanced esophageal cancer]

 

受賞

・2017-2018: The 31st International Student Scholarship Grant for Research in Basic Medical Sciences and Medical Care from the Ichiro Kanehara Foundation

・2013-2016: Granted research from “The Program for Cultivating Global Leaders in Heavy Ion Therapeutics and Engineering”, Gunma University.

・2013 – 2017: Scholarships from “The Program for Cultivating Global Leaders in Heavy Ion Therapeutics and Engineering”, Gunma University.

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